Yes!  Ibuprofen and other drugs that belong to non steroidal anti inflammatory drug class like aspirin, excedrin, motrin, advil, aleve etc. can interfere with ovulation.  A study published in Journal of Clinical Pharmacology  (Bata MS, Al-Ramahi M, Salhab AS, Gharaibeh MN, Schwartz J. Delay of ovulation by meloxicam in healthy cycling volunteers: A placebo-controlled, double-blind, crossover study. J Clin Pharmacol. 2006 Aug;46(8):925-32) showed that women who took NSAID medication had delayed ovulation by approximately 5 days, decreased levels of serum progesterone in the second part of the cycle and increased …